Hot Melt Extrusion Essay Example | Topics and Well Written Essays - 750 words

Hot Melt Extrusion - Essay object lessonHME technique does not require condemnation consuming drying step and compressing step and therefore, the processing locomote are significantly reduced. Due to fewer unit operations involved in HME operation, production time is greatly enhanced. During the HME process, the polymer-melt itself act as a thermal binder. HME eliminates problems arising from poorly compactible materials. An extruded rod obtained from HME procedure can be directly incorporated into tablets after cutting. Uniform dispersion of fine particles is obtained due to vigorous mixing and zymolysis conditions of HME operation. The energy requirements in HME process are low as compared to high shear granulation. The HME process requires press down investment for equipment as against other processes. HME technique also provides new strategies to increase dissolution rates for sparingly water soluble drugs, enhance bioavailability of the active ingredient, improve content uniformity of dosage formulation, modify drug release, and also helps to mask the unpleasant taste of the drug (Repka et al. 1043 Crowley et al. 909).A single- or twin-screw extruders are used for HME process. The extruder is be of a feeding hopper, barrels, single or twin screws, die, screw-driving unit, heating/cooling device for the barrels, conveyer belted ammunition to cool down the product, and solvent delivery pump. The monitoring devices on the equipment include temperature gauges, a screw-speed controller, an extrusion tortuousness monitor and pressure gauges.During the HME process, first a dry powder blend of drug, polymer, and other adjuvants/additives is prepared. Then, this soild mixture is federal official into the feeding sectionalisation of the extruder. The material is transferred to the melting section. The heat is applied to the material in the melting section to form the polymer-melt. This molten mass is transferred in the metering section which is then